Products – Al-Effat

Chicktetra 70%

Composition: - Each 1 gm contains Oxytetracycline hydrochloride 757 mg Equi. To oxytetracycline base 700 mg Properties :

Oxytetracycline is a broad-spectrum antibiotic. It is mainly active against Gram-positive and Gram negative bacteria, aerobic and anaerobic, mycoplasma, Chlamydia and Rickettsiae It acts by reversibly to the ribosomal subunit 30S receptors to a blockage of the union between aminoacyl-tRNA to the site corresponding to the mRNA-ribosome complex messenger. Then inhibition of the protein synthesis and inhibits bacterial growth. Indications: Chicktetra is used for the treatment of: Broiler chickens: *Arthritis caused by Staphylococcus aureus. *Chronic Respiratory Disease (CRD) caused by Mycoplasma gallisepticum. *Infectious enteritis caused by E. coli. *Fowl cholera caused by Pasteurella multocida. *Fowl coryza caused by Haemophilus paragallinarum. *Gangrenous dermatitis caused by Clostridium spp. *Typhoid & paratyphoid caused by Salmonella spp. Pre – ruminating calves: *Bovine pneumonia caused by Mycoplasma bovis , Pasteurella haemolytica , P. multocida & Haemophilus somnus. *Scours , neonatal diarrhea caused by E. coli & Salmonella spp. Target Species Broiler Chickens ,pre-ruminating calves Dosage and administration:

by addition to drinking water From active ingredient : Broiler chickens: 20mg of oxytetracycline /kg body weight 3-5 days Pre – ruminating calves: 10-30 mg / kg bodyweight 1-2 times daily From whole product Broiler chickens: 0.5 gm of product / liter of drinking water 3-5 days Pre – ruminating calves: 2.5gm7.5gm of product /100 kg body weight 1-2 times daily Warning and precautions : Should be dissolved in water, before use. Prolonged or repeated use should be avoided Do not use in laying birds producing eggs intended for human consumption Contra indications hypersensitivity to oxytetracycline or any other substance from tetracyclines group. Side effects: gastro-intestinal disorder and less frequently, allergic and photosensitivity reactions. Interaction with other drugs: should not be administered with antacids, gels containing aluminium, preparations containing vitamins or minerals as insoluble complexes will be formed, which decreases the absorption of the antibiotic. Withdrawal period Meat and offal:7 days Eggs: do not use in laying birds producing eggs intended for human consumption Storage: Keep on cool &dry place not exceeding 30° C. Keep out of reach of children. Manufactured by Eva pharm distribution by "Aleffat trading "

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EVA GERM

Antibiotics

COMPOSITION: Each 1 gm contains: Ampicillin (as Ampicillin Trihydrate) 346.5 mg

Ampicillin base 300mg

INDICATIONS AND PROPERTIES: Ampicillin is indicated for the treatment of infections caused by E.coli, Clostridium, Salmonella, Brucella, Proteus, Klebsiella, Strepto and Staphylococci, Corynebacterium, Haemophilus, Pasteurella, and Shigella in the different animals. EVAGERM30%: is recommended for uses in cases of Bacterial enteritis and Necrotic enteritis in poultry. It is also indicated Against Pneumonia, Septicemia, Diarrhea, and Scours in calves and lambs.

DOSAGE AND ADMINISTRATION: – Poultry: 1 gm per 2 liter of drinking water for (3 – 5) days. – Other animals: 1 -2.5 mg per 10 kg body weight daily (20 – 50 mg Ampicillin per 1 kg body weight). In acute and chronic cases can be given twice daily.

CONTRA-INDICATIONS AND WARNINGS: Do not use orally for adult ruminants.

WITHDRAWAL PERIOD: Poultry: 1 day. Calves: 15 days before slaughtering.

STORAGE: Store at a temperature below 30 C. Store in a dark place.

PACKAGE:

500 g

Manufactured by Eva pharm distribution by "Aleffat trading "

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Hexacycline

Antibiotics

Composition : Each 1 gm contains: - Doxycycline (as hyclate) 400 mg + Bromhexine (as hydrochloride) 40 mg Properties : Doxycycline: has broad spectrum activity inhibiting both aerobic and anaerobic gram-posi�tive and gram-negative bacteria, mycoplasmas, chlamydiae, rickettsias and some protozoa. Bromhexine is a mucoregulator. By activating the secretion of the seromucous glands, It breaks down the network of acid glycoprotein fibres found in mucoid sputum, which are mainly responsible for the characteristic viscosity. Mechanism of Action: Doxycycline inhibits bacterial protein synthesis. Doxycycline binds to the 30S ribosomal subunit, which prevents the tRNA from binding to the ribosome. This prevents the mRNA from being translated into protein, which is essential for bacterial growth and reproduction. Bromhexine acts by inhibiting neuraminidase, stabilizing lysosomes, increasing ciliary activity, hydrating mucus, and exhibiting anti-inflammatory effects. Strength points of Hexacycline: Hexacycline Synergistic effect: Doxycycline is a broad-spectrum antibiotic that is effective against a wide range of bacteria, including Mycoplasma gallisepticum, which is a common cause of respiratory infections in poultry. Bromhexine is an expectorant that helps to loosen mucus and clear congestion. When used together, doxycycline and bromhexine can be more effective than either drug alone in treating respiratory infections. Hexacycline Improved absorption: Bromhexine can help to improve the absorption of doxy�cycline, which means that it is effective in the lower doses. Hexacycline is effective against a wide range of Gram-positive and Gram-negative bacteria, making it a versatile antibiotic for poultry. Hexacycline has a long half-life, meaning it remains in the body for an extended period, providing prolonged protection against bacterial infections. Hexacycline Reduced Respiratory Distress: By assisting in clearing mucus and improving airway function, bromhexine may contribute to reducing respiratory distress in affected poultry Dose of whole product: Broilers chickens: 0.5 gm of the product / 1 liter drinking water Produced by EVA PHARMA distributor by Aleffat trading

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Tylosol

Antibiotics

Composition: - Tylosin tartarate 110gm Equivalent to Tylosin 100 gm Properties : Tylosin is a macrolide antibiotic which acts by inhibiting bacterial protein synthesis through binding to 50S ribosomal subunits within cell wall . It has antibacterial spectrum that is essentially against gram +ve bacteria including (Actinomyces spp . Erysipelothrix rhusiopathiae), certain gram – ve. bacteria including Pasteurella spp and Fusobacterium necrophorum)and certain Spirochetes (as Treponema hyodysenteriae). Indications: Pre ruminant Calves: Treatment of pneumonia caused by Mycoplasma spp when the disease has been established in the herd. Broiler Chickens: Treatment of chronic respiratory diseases (CRD) caused by Mycoplasma gallisepticum and Mycoplasma synoviae when the disease has been established in the flock. Treatment and prevention of necrotic enteritis caused by Clostridium perfringens when the disease has been established in the flock Turkeys: Treatment of infectious sinusitis caused by Mycoplasma gallisepticum. when the disease has been established in the flock Target species: Broiler Chickens, pre ruminate Calves, Turkeys Dosage and administration: by addition to drinking water From active ingredient Pre ruminant Calves: 10 – 20 mg tylosin per kg BW twice daily for 7 - 14 days. Turkeys: 75 – 100 mg tylosin per kg BW per day for 3 – 5 days Broiler Chickens: For the treatment of chronic respiratory disease: 75 – 100 mg tylosin per kg BW per day for 3 – 5 days. From whole product Pre ruminant Calves: 0.54 gm-1.08gm of product per 50 kg BW twice daily for 7 - 14 days. Turkeys: 0.81 gm –1.082 gm /10 kg BW( 1 liter ) per day for 3 – 5 days Broiler Chickens: 0.81 gm –1.082 gm /10 kg BW( 1 liter ) day for 3 – 5 days Contra indications: It shouldn’t be used in layers producing eggs for human consumption Drug interactions Because tylosin is related to macrolides group, it interacts with Clindamycin (increase antagonism of effect) Side effects:Diarrhoea, epigastric pain Withdrawal period: Pre ruminant Calves (meat and offal): 12 days Turkeys (meat and offal): 2 days, Turkey (eggs): Zero days Broiler Chickens (meat and offal): 1 day, Chicken (eggs): Zero days Manufactured by Eva pharm distribution by "Aleffat trading "

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VIEWCOXOL

Antibiotics, Anticoccidial

COMPOSITION: Each 1 gm conta ins: Amprollum HCL 240 mg

Amprollum base 212mg

VIEWCOXOL 21.2%(amprolium) is an anticoccidial used to prevent, treat, and allow immunity of coccidiosis depending on the type of poultry. The most common coccidia in chickens include Eimeria acervulina, E. maxima, E. tenella, E. brunetti, E. praecox, E. mitis and E. necatrix. The most common coccidia in turkeys include E. meleagrimitis, E. adenoides, E. gallopovonis and E. meleagridis. In pheasants VIEWCOXOL 21.2%(can be used for prevention of E. colchici, E. duodenalis and E. phasianti.

Benefits

VIEWCOXOL 21.2%( (amprolium)

Can be administered through the feed

Can be used safely in chickens and turkeys of all ages

Safe in poultry due to its therapeutic activity

Zero day withdrawal period

Minimum risk of residual substances for consumers

Indication

VIEWCOXOL 21.2%( (amprolium) can be used through the life cycle of birds from day-old chicks to the day of slaughter and is intended for use in (1) preventing outbreaks of coccidiosis in growing chickens, turkeys and pheasants and (2) development of active immunity to coccidiosis in replacement chickens. VIEWCOXOL 21.2%( is also intended for use in the prevention and treatment of coccidiosis in laying chickens

Dosage and administration

For oral administration via feed or water: - Broilers: Preventive dose: 480 g per 1000 litres of drinking water or 1000 kg of feed given to chickens starting from the 3-5 day of life. Curative dose: 960 g per 1000 litres of drinking water or 1000 kg of feed for 7 - 10 days. - Replacement chickens and breeders: Preventive dose: 480 g per 1000 kg of feed given to chickens starting from the 3-5 day of life up to 16 weeks of age. Curative dose: 960 g per 1000 kg of feed for 7 - 10 days. In drinking water use: Preventive dose: 240 g per 500 litres of drinking water given to chickens starting from the 3-5 day of life up to 21st day of life. Curative dose: 480 g per 500 litres of drinking water for 5-7 days. No other source of drinking water should be available during the medication period. - Calves, sheep: Curative dose: 0,04 g per kg body weight once daily for 5 days. In severe outbreak the dose can be doubled. Preventive dose for calves: 0,028 g per kg body weight for 21 days. Preventive dose for sheep: 0,028 g per kg body weight for 5 days. Manufactured by Eva pharm distribution by "Aleffat trading "

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Zurilex

Antibiotics, Anticoccidial

Composition: Each 1 ml contain: Toltrazuril 25 mg

Properties: Toltrazuril induces changes in the fine structure of coccidial development stages that are mainly due to the swelling of the endoplasmic reticulum and of the Golgi apparatus and to abnormalities in the perinuclear space and disturbances in nuclear division. Toltrazuril also causes a reduction of enzymes in the respiratory chain of the parasites. Pharmacodynamic studies in laboratory animals indicated that toltrazuril had no anticoagulant, fibrinolytic, analgesic, diuretic or anticonvulsant effect. It had no effect on gastrointestinal transit time. Oral doses of up to 30 mg/kg bw had no haemodynamic or cardiac effects in anaesthetised dogs although 100mg/kg bw caused a slight tensor effect as reflected by an increase in peripheral resistance Indications: For the treatment and control of coccidiosis, Toltrazuril is effective against all intestinal stages of susceptible coccidia. To assist in the development of natural immunity to coccidiosis in breeder and layer replacer stock exposed to continuous challenge of virulent strains of coccidian Target species: Broilers and Broiler Breeders Dosage & administration: orally in drinking water. Active ingredient 7 mg / kg body weight Whole product 280ml /100kg body weight in drinking water for 25 successive days (2.5-3 ml/L) Warnings & precautions: This product is compatible with antibiotics such as enrofloxacin, ampicillin, tetracycline, tiamulin and tylosin. Contra – indication: Not to be used with chickens produces eggs for human consumption. Side – effects: No side effects in the recommended dose. Withdrawal time: 21 day Storage: Stored at temp. not exceed 30 °C Manufactured by Eva pharm distribution by "Aleffat trading "

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